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Dr. Saleh Hussain A Almasabi
- Faculty Member
- Assistant Professor of Histopathology and Cytopathology
- Department of Clinical Laboratory Sciences
- College of Applied Medical Sciences
Qualifications
- Doctor of Philosophy (PhD) – Monash University, Australia (2023)
- Thesis Title: Investigation of Integrin-Linked Kinase (ILK) as a Therapeutic Target in Colorectal Cancer
- Master of Medical Laboratory Science (Specialization: Histopathology and Cytopathology) – RMIT University, Australia (2016)
- Research Project: In collaboration with the University of Melbourne on the role of TGF-? in breast cancer cell metastasis
- Bachelor of Medical Laboratory Sciences – Najran University, Kingdom of Saudi Arabia (2013)
Experiences
Professional Experience and Academic Roles
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Head of the Clinical Laboratory Department – Najran University Hospital
(September 2023 – Present) -
Member of the Executive Committee – Najran University Hospital
(September 2023 – Present) -
Teaching Histology and Physiology Courses
(2023 – Present) -
Internship (Clinical Training) – King Khalid Hospital, Najran
(2012, duration: ? months) -
Chairman of the Internship Committee
(July 2023 – Present) -
Member of the Timetable and Examination Committee
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Member of the Final Examination Committee
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Member of the Community Service Committee
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Member and Representative of the Histopathology and Cytopathology Track in the Master’s Program Committee
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Member of the Student Excuse Committee
Specialties and Skills
Technical Skills
Word ، Excel، PowerPoint، SPSS، GraphPad Prism، ImageJ، OlyVIAGEO، TIMER، Oncomine، GEPIA، cBioPortal، Human Protein Atlas، GENT2
Lab Skills
Histological & cytological special stains, Immunohistochemistry (IHC), Immunocytochemistry (ICC), In Situ Hybridization, Light & fluorescent microscopy, Molecular cloning & recombinant protein expression, PCR & DNA quantification using fluorescent assays, Cell culture techniques (2D & 3D), Western blotting & luciferase assay, Immunofluorescence staining & time-course experiments, Adenoviral reporter optimization (MOI, protein expression, half-life), Creating stable GFP cell lines & tracking single labelled cells, Fluorescence signal analysis using ImageJ, Gene knockout using CRISPR/Cas9, Cell proliferation (Alamar Blue, CLARIOstar), Colony Formation Assay (Crystal Violet), Cytotoxicity assay via immune cell co-culture with cancer cells, Multiplex immunofluorescence staining (CRC tissue microarray)Training Courses
Courses and Workshops Attended
- Data Quality
- Preparing Faculty Members for Academic Accreditation
- Expected Questions During Program Academic Accreditation Visits
- Administrative Supervision
- Orientation Program for New Teaching Staff for Professional Development
- Change Management
Workshops Delivered
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“Laboratory Quality and Preventive Maintenance”
Research interests
Tumor Microenvironment (TME)
Inflammation and Its Role in Cancer Development
Immune Evasion in Solid Tumors
Immunotherapy and Molecular Therapy of Solid Cancers
Application of CRISPR/Cas9 Technology in Solid Cancer Research
Gene Expression Data Analysis (Bioinformatics)
Publications
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A Potential Role for Integrin-Linked Kinase in Colorectal Cancer Growth and Progression via Regulating Senescence and Immunity
Frontiers in Genetics, 2021 -
Integrin-Linked Kinase Expression Characterizes the Immunosuppressive Tumor Microenvironment in Colorectal Cancer and Regulates PD-L1 Expression and Immune Cell Cytotoxicity
Frontiers in Oncology, 2022 -
Integrin-Linked Kinase Expression in Myeloid Cells Promotes Colon Tumorigenesis
Frontiers in Immunology, 2023 -
Delineating Pixantrone Maleate’s Adroit Activity against Cervical Cancer Proteins through Multitargeted Docking-Based MM/GBSA, QM-DFT, and Molecular Dynamics Simulation
PLoS ONE, 2023 -
Alternative Use of Droxidopa for Treating Cervical Cancer: Inhibiting Transferase, Cell Cycle Signalling, and Transport Proteins via Multitarget Docking, DFT, MD Simulations, and Binding Free Energy Studies
Medical Oncology, 2025 -
Effects of Atranorin on the Proliferation, Apoptosis, and Metastasis of Two Different Gastric Cancer Cell Lines and Exploring Underlying Mechanisms
Molecular Biology Reports, 2026
Conferences
- The role of ILK in senescence and immunosuppressive tumor microenvironment in colorectal cancer” Eradicate Cancer conference 2020.
- A potential role for integrin-linked kinase in the tumor microenvironment and cellular senescence in colorectal cancer” Cell Signalling and The Therapeutic Implications 2021.
- Histopathological Techniques
- Histopathology2
- Basics of Histology
- Human Physiology
| 8-9 | 9-10 | 10-11 | 11-12 | 12-1 | 1-2 | |
|---|---|---|---|---|---|---|
Sunday |
Office 288 | Lecture | Lecture | Lecture | NUH Lab | |
Monday |
Office 288 | Department Council | Office 288 | Lecture | ||
Tuesday |
Lecture | Lecture | Lecture | Lecture | Office 288 | Lecture |
Wednesday |
Lecture | Lecture | Lecture | Lecture | Lecture | Office 288 |
Thursday |
NUH Lab | NUH Lab | NUH Lab | NUH Lab | NUH Lab |